Ongoing Cardiovascular CT Projects
Copenhagen General Population Study
Project summary
The Copenhagen General Population Study (Herlev-Østerbroundersøgelsen) is a prospective cohort study of the general Danish population. The purpose of this cohort study is to investigate prevalent population-based morbidities while establishing correlations among lifestyle, genetics, and diseases to optimize preventive measures. Study participants were randomly selected inhabitants aged 20 to 100 years living within and surrounding Copenhagen areas. The study has garnered the participation of over 100.000 Danes. They have contributed by completing detailed questionnaires, providing blood samples, and undergoing physical examinations at Herlev Hospital.
In 2010, the Danish National Committee on Health Research Ethics granted permission to conduct cardiac CT scans on participants aged 40 and above as part of the Copenhagen General Population Study. This approval was granted due to the feasibility of maintaining a relatively low total radiation dose. Cardiac CT scans were performed at Rigshospitalet and over 10.000 participants from the Copenhagen General Population Study have undergone cardiac CT examination. Over the years, cardiac CT imaging has established its significance in uncovering novel cardiovascular biomarkers.
Read more here:
CGPS Official Website
DANE-HEART
Project summary
The goal of this randomized controlled clinical trial in asymptomatic individuals with risk factors for cardiovascular disease is to investigate whether a preventive treatment strategy guided by computed tomography coronary angiography (CTCA) provides a patient-centered approach, which ensures optimal protection against serious cardiovascular disease.
Main question this project aims to answer
Does preventive treatment guided by CTCA reduce the risk of heart attacks or cardiovascular death as compared to using conventional cardiovascular risk scores. Participants will be randomized to preventive medical therapy and/or invasive intervention guided by either CTCA (intervention group) or Systematic COronary Risk Evaluation (SCORE) 2 model for cardiovascular risk prediction (control group).
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Study Protocol
DYNAMITE
Project summary
The purpose of the DYNAMITE trial (Dynamic CT stress myocardial perfusion, CT fractional flow reserve (FFR-CT) and coronary CT angiography for optimized treatment strategy in patients with chest pain syndromes) is to determine the ability of combined anatomical and functional cardiac CT imaging to improve morbidity and mortality in patients with suspected or known ischemic heart disease.
Main question this project aims to answer
Does a treatment strategy guided by combined dynamic CT myocardial stress perfusion, FFR-CT and CT coronary angiography 1) improve clinical outcome and 2) improve symptom relief compared with a conventional management strategy in patients with chronic chest pain syndromes.
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Study Protocol
Inter99
Project summary
A population-based study commenced in 1999 including 6784 Danish citizens aged 30 to 60 years, examining the effect of interventional lifestyle counselling on the development of major adverse cardiovascular events (MACE). The aim is now to re-examine the population in all the alive (n=6004) Inter99 participants. Re-examinations will include physical examinations, biochemical measurements, and cardiac CT-scans. The cardiac CT-scans will include extensive information and readings on both the cardiac health as well as lungs, bones, and abdominal organ
Main question this project aims to answer
The estimated 1500 cardiac CT-scans will form the basis of many studies. Current projects:
– The InterVitaminK trial: Data on the coronary calcification is used for screening of participants and inclusion for a randomized controlled intervention study.
– A PhD project investigating the correlation between vitamin K status and coronary calcification: Does a lower vitamin K status escalate the progression of coronary calcification and high-risk plaques compared to higher vitamin K status?
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Study Protocol
InterVitaminK
Project summary
The InterVitaminK trial is a prolongation of the Inter99 study and will investigate the cardiometabolic and bone health of the participants and the development of chronic disease after a 3-year intervention. Participants will be randomized to receive a daily dosage of 333 µg vitamin K or placebo. The trial will conclude with a follow-up cardiac CT-scan.
Main question this project aims to answer
Does a daily dosage of vitamin K supplement affect the risk of chronic disease, including among others: 1) the progression of coronary calcification, 2) the bone metabolism, 3) the metabolic health, 4) the lung function?
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Study Protocol
Inten-CT
Project summary
Some people with type 2 diabetes have a very low risk of developing cardiovascular diseases and blood clots, while others have a high risk. It varies from person to person. However, the treatment is often the same, which leads to both under- and overtreatment. This is the background for the scientific study Inten-CT: We want to investigate whether the treatment for the individual patient can be targeted through a thorough examination for early cardiovascular disease.
Main question this project aims to answer
1) Do screening detected high-risk patients benefit of intensified medical treatment 2) Is it safe to de-intensify medical treatment among patients with a screening detected low risk of CVD? 3) Does a CVD screening and treatment program improve patient reported health status?
Read more here:
Study Protocol
Visit Inten-CT’s official webpage:
Webpage link
TraCTion
Project summary
Coronary computed tomography angiography (CCTA) is a widely accepted initial diagnostic test for individuals suspected of having chronic coronary syndromes. However, there is limited evidence supporting its use in the acute setting. So far, no large-scale randomized trial has examined the performance of CCTA as an alternative to invasive coronary angiography (ICA) in individuals with non-ST-segment elevation myocardial infarction (NSTEACS).
Main question this project aims to answer
If CCTA were to replace ICA as a routine procedure for individuals with NSTEACS, it could reduce the risk of complications related to ICA, improve patient comfort, expedite decision-making, and reduce healthcare expenses and interhospital transfers.
Read more here:
Study Protocol
Other cardiac CT projects
COCOMO
Copenhagen Co-morbidity in HIV Infection Study
Study Protocol
DACOLT
The Danish Comorbidity in Liver Transplant Recipients Study
Study Protocol
CPH-PRECIOUS
The CoPenHagen PREeClampsia and cardIOvascUlar diSease Study
Study Protocol
NOTION-4
The Nordic Aortic Valve Intervention Trial
Study Protocol
GLORIOUS-II
Tocilizumab, Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery
Study Protocol
NEO Trial-II
Neurological Complications Comparing Endoscopically vs. Open Harvest of the Radial Artery
Study Protocol